Anti-TGF beta antibody

[STJ95997] Download PDF Print Data Sheet

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Product name Anti-TGF beta antibody
Short Description Rabbit polyclonal against TGF beta
Description TGF-beta 1 is a protein encoded by the TGFB1 gene which is approximately 44,3 kDa. TGF-beta 1 is secreted into the extracellular space and matrix and is involved in apoptotic pathways in synovial fibroblasts, SMAD2/3 MH2 domain mutants in cancer, Th17 differentiation pathway, GPCR pathway and ERK signalling. This protein falls under the TGF-beta superfamily which bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. It is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. TGF-beta 1 is highly expressed in bone. Mutations in the TGFB1 gene may result in Camurati-Engelmann disease and Cystic Fibrosis, Renal Fibrosis. STJ95997 was developed from clone 5D2. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This mouse monoclonal antibody detects endogenous levels of TGF-beta 1.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Specificity TGFbeta1 Polyclonal Antibody detects endogenous levels of TGFbeta1 protein.
Protein Name Transforming growth factor beta-1
Latency-associated peptide
Immunogen Synthesized peptide derived from human TGFbeta1
Immunogen Region 310-390 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IF IHC WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7040
Gene Symbol TGFB1
Molecular Weight 44 kDa
Database Links HGNC:11766
Alternative Names Transforming growth factor beta-1
Latency-associated peptide
Swiss-Prot Key P01137_HUMAN
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