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Anti-AR-β3 antibody

[STJ91728] Download PDF Print Data Sheet

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Product name Anti-AR-β3 antibody
Short Description Rabbit polyclonal to AR-β3.
Description AR-β3 is a protein encoded by the ADRB3 gene which is approximately 43,5 kDa. AR-β3 is localised to the cell membrane. It is involved in peptide ligand-binding receptors, activation of cAMP-dependent PKA, signalling by GPCR and DAG and IP3 signalling. It mediates catecholamine-induced activation of adenylate cyclase through the action of G proteins and is involved in the regulation of lipolysis and thermogenesis. AR-β3 is expressed mainly in adipose tissue. Mutations in the ADRB3 gene may be involved in diabetes mellitus and obesity. STJ91728 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AR-β3 protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:20000
Specificity AR-β3 Polyclonal Antibody detects endogenous levels of AR-β3 protein.
Protein Name Beta-3 adrenergic receptor
Beta-3 adrenoreceptor
Beta-3 adrenoceptor
Immunogen Synthesized peptide derived from human AR-β3
Immunogen Region 220-300 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 155
Gene Symbol ADRB3
Molecular Weight 36 kDa
Database Links HGNC:288
OMIM:109691
Alternative Names Beta-3 adrenergic receptor antibody
Beta-3 adrenoreceptor antibody
Beta-3 adrenoceptor antibodyR antibody
B3AR antibody
Function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Cellular Localization Cell membrane. Multi-pass membrane protein.
Tissue Specificity Expressed mainly in adipose tissues.
Swiss-Prot Key P13945_HUMAN
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