Anti-ARHGEF1 Antibody

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Product name Anti-ARHGEF1 Antibody
Short Description Rabbit polyclonal to ARHGEF1
Description Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Rho guanine nucleotide exchange factor 1
115 kDa guanine nucleotide exchange factor
p115-RhoGEF
p115RhoGEF
Sub1.5
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_004697.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 9138
Gene Symbol ARHGEF1
Molecular Weight 102.435 kDa
Database Links HGNC:681
OMIM:601855
Reactome:R-HSA-193648
Alternative Names Rho guanine nucleotide exchange factor 1
115 kDa guanine nucleotide exchange factor
p115-RhoGEF
p115RhoGEF
Sub1.5
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits, Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase, Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain, This GEF activity is inhibited by binding to activated GNA12, Mediates angiotensin-2-induced RhoA activation,
Post-translational Modifications Phosphorylated by PKCA, Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2,
Cellular Localization Cytoplasm,
Tissue Specificity Ubiquitously expressed
Swiss-Prot Key Q92888
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