Anti-Calnexin antibody (KLH)

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Product name Anti-Calnexin antibody (KLH)
Short Description Mouse monoclonal against Calnexin (KLH)
Description Mouse monoclonal to Calnexin (KLH).
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Specificity Calnexin Monoclonal Antibody detects endogenous levels of Calnexin protein.
Protein Name Calnexin
IP90
Major histocompatibility complex class I antigen-binding protein p88
p90
Immunogen Synthesized peptide derived from human Calnexin, conjugated to KLH.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IF WB
Host Mouse
Clonality Monoclonal
Clone ID 3H4A7
Reactivity Human
Conjugation KLH
Purification Affinity purification
Isotype IgG2b
Formulation Ascitic fluid containing 0.03% sodium azide.
Gene ID 821
Gene Symbol CANX
Database Links HGNC:1473
OMIM:114217
Alternative Names Calnexin
IP90
Major histocompatibility complex class I antigen-binding protein p88
p90
Function Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Post-translational Modifications Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes . Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins. Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
Cellular Localization Endoplasmic reticulum membrane Endoplasmic reticulum Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV . The palmitoylated form preferentially localizes to the perinuclear rough ER .
Swiss-Prot Key P27824_HUMAN
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