Anti-Calregulin antibody (KLH)

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Product name Anti-Calregulin antibody (KLH)
Short Description Mouse monoclonal against Calregulin (KLH)
Description Mouse monoclonal to Calregulin (KLH).
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
ELISA 1:10000
Specificity Calregulin Monoclonal Antibody detects endogenous levels of Calregulin protein.
Protein Name Calreticulin
Endoplasmic reticulum resident protein 60
Immunogen Synthesized peptide derived from human Calreticulin, conjugated to KLH.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IF IHC WB
Host Mouse
Clonality Monoclonal
Clone ID 1G6A7
Reactivity Human, Mouse
Conjugation KLH
Purification Affinity purification
Isotype IgG2a
Formulation Ascitic fluid containing 0.03% sodium azide.
Gene ID 811
Gene Symbol CALR
Database Links HGNC:1455
Alternative Names Calreticulin
Endoplasmic reticulum resident protein 60
Function Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis .
Cellular Localization Endoplasmic reticulum lumen Cytoplasm, cytosol Secreted, extracellular space, extracellular matrix Cell surface Sarcoplasmic reticulum lumen. Also found in cell surface (T cells), cytosol and extracellular matrix . Associated with the lytic granules in the cytolytic T-lymphocytes.
Sequence and Domain Family Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.; The interaction with glycans occurs through a binding site in the globular lectin domain.; The zinc binding sites are localized to the N-domain.; Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
Swiss-Prot Key P27797_HUMAN
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