Anti-CAR antibody

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Product name Anti-CAR antibody
Short Description Rabbit polyclonal against CAR
Description Rabbit polyclonal to CAR.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:20000
Specificity CAR Polyclonal Antibody detects endogenous levels of CAR protein.
Protein Name Coxsackievirus and adenovirus receptor
CAR
hCAR
CVB3-binding protein
Coxsackievirus B-adenovirus receptor
HCVADR
Immunogen Synthesized peptide derived from human CAR
Immunogen Region 10-90 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1525
Gene Symbol CXADR
Molecular Weight 40 kDa
Database Links HGNC:2559
OMIM:602621
Alternative Names Coxsackievirus and adenovirus receptor
CAR
hCAR
CVB3-binding protein
Coxsackievirus B-adenovirus receptor
HCVADR
Function Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C . Acts as a receptor for Coxsackievirus B1 to B6 .
Post-translational Modifications N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.
Cellular Localization Isoform 1: Cell membrane Basolateral cell membrane Cell junction, tight junction Cell junction, adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions . In airway epithelial cells localized to basolateral membrane but not to apical surface . Isoform 3: Secreted Isoform 4: Secreted Isoform 5: Secreted
Tissue Specificity Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elev
Sequence and Domain Family The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.; The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.
Swiss-Prot Key P78310_HUMAN
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