Anti-CD207 antibody (Alexa-fluor 488)

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Product name Anti-CD207 antibody (Alexa-fluor 488)
Short Description Mouse monoclonal against CD207 (Alexa-fluor 488)
Description Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)
Applications FC, IF
Protein Name C-type lectin domain family 4 member K
Langerin
CD antigen CD207
Immunogen In vitro-derived human DCs from CD34+ cells in GM-CSF+TNFa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application FC IF
Host Mouse
Clonality Monoclonal
Reactivity Canine, Human
Conjugation Alexa-fluor 488
Concentration 0.5 mg/ml
Purification QMA Hyper D ion exchange chromatography
Formulation PBS 50% glycerol
Gene ID 50489
Gene Symbol CD207
Molecular Weight 36.725 kDa
Database Links HGNC:17935
OMIM:604862
Reactome:R-HSA-1236978
Alternative Names C-type lectin domain family 4 member K
Langerin
CD antigen CD207
Function Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Cellular Localization Membrane
Tissue Specificity Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Swiss-Prot Key Q9UJ71
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