SHOPPING BASKET: 0 item(s) - £0.00  

You have no items in your shopping cart.

Anti-CD4 antibody

[STJ96972] Download PDF Print Data Sheet
2 days

* Required Fields

£0.00
Product name Anti-CD4 antibody
Short Description Mouse monoclonal to CD4.
Description CD4 is a protein encoded by the CD4 gene which is approximately 51,1 kDa. CD4 is localised to the cell membrane and endoplasmic reticulum. It is involved in the TGF-beta pathway, PEDF induced signalling and the T-cell receptor signalling pathway. It is a membrane glycoprotein of T-lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. It initiates or augments the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. CD4 is expressed in the blood, cells of the nervous system, liver, pancreas and spleen. STJ96972 was developed from clone 11A1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous CD4 proteins.
Applications IHC
Dilution range IHC 1:200
Specificity The antibody detects endogenous CD4 proteins.
Protein Name T-cell surface glycoprotein CD4
T-cell surface antigen T4/Leu-3
CD antigen CD4
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 11A1
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 920
Gene Symbol CD4
Database Links HGNC:1678
OMIM:186940
Alternative Names T-cell surface glycoprotein CD4 antibody
T-cell surface antigen T4/Leu-3 antibody
CD antigen CD4 antibody
Function Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.; (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 . Down-regulated by HIV-1 Vpu . Acts as a receptor for Human Herpes virus 7/HHV-7 .
Post-translational Modifications Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular Localization Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Swiss-Prot Key P01730_HUMAN
Bad Good
Enter the code in the box below:

Ask us a question

0
Please can you let me know the region STJ96972 binds to?
Question by: Guest on 11 Apr 2018 16:02:00
2
Hi, thank you for your query. Anti-CD4 antibody [STJ96972] binds to the N-terminal.
Answer by: Customer Support on 11 Apr 2018 16:04:00
-2
I am interested in this antibody in 0.3mg size, 1mg/mL. Would it be possible to change the storage buffer to PBS and not include sodium azide?
Question by: Guest on 11 Apr 2018 12:40:00
-8
Hello, thank you for your query. If you would like to place a custom order, the product should be at least 1 mg. There will be no additional cost for changing the storage buffer. Please contact us at info@stjohnslabs.com for further information.
Answer by: Customer Support on 11 Apr 2018 12:43:00

Tags:

Use spaces to separate tags. Use single quotes (') for phrases.