Anti-CD40 antibody (Alexa-fluor 488)

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Product name Anti-CD40 antibody (Alexa-fluor 488)
Short Description Mouse monoclonal to CD40 (Alexa-fluor 488)
Description CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin
Applications FC, IF
Protein Name Tumor necrosis factor receptor superfamily member 5
B-cell surface antigen CD40
Bp50
CD40L receptor
CDw40
CD antigen CD40
Immunogen anti-u activated tonsillar human B cells
Storage Instruction Store at -20◦C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application FC IF
Host Mouse
Clonality Monoclonal
Reactivity Human
Conjugation Alexa-fluor 488
Concentration 0.5 mg/ml
Purification QMA Hyper D ion exchange chromatography
Formulation PBS 50% glycerol
Gene ID 958
Gene Symbol CD40
Molecular Weight 30.619 kDa
Database Links HGNC:11919
OMIM:109535
Reactome:R-HSA-198933
Alternative Names CD40 (Alexa-fluor 488)
Tumor necrosis factor receptor superfamily member 5 antibody
B-cell surface antigen CD40 antibody
Bp50 antibodyL receptor antibody
CDw40 antibody
CD antigen CD40 antibody
TNFRSF5 antibody
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Cellular Localization Cell membrane
Tissue Specificity B-cells and in primary carcinomas.
Swiss-Prot Key P25942
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