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Anti-Cleaved-Caspase-1 (D210) antibody

[STJ90001] Download PDF Print Data Sheet

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Product name Anti-Cleaved-Caspase-1 (D210) antibody
Short Description Rabbit polyclonal to Cleaved-Caspase-1 (D210).
Description Caspase-1 is a protein encoded by the CASP1 gene which is approximately 45,1 kDa. Caspase-1 is localised to the cytoplasm. It is involved in amyotrophic lateral sclerosis, toll-like receptor signalling pathways, p53 signalling and the TNFR1 pathway. This protein falls under the the cysteine-aspartic acid protease family. upon activation It plays a central role in the execution-phase of cell apoptosis. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules. Caspase-1 is expressed mainly in the spleen and lung. Mutations in the CASP1 gene may result in shigellosis and cowpox. STJ90001 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated Caspase-1 protein resulting from cleavage adjacent to D210.
Applications ELISA, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Specificity Cleaved-Caspase-1 (D210) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.
Protein Name Caspase-1
CASP-1
Interleukin-1 beta convertase
IL-1BC
Interleukin-1 beta-converting enzyme
ICE
IL-1 beta-converting enzyme
p45
Caspase-1 subunit p20
Caspase-1 subunit p10
Immunogen Synthesized peptide derived from human Caspase-1
Immunogen Region 130-210 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 834
Gene Symbol CASP1
Molecular Weight 25/45 kDa
Database Links HGNC:1499
OMIM:147678
Alternative Names Cleaved-Caspase-1 (D210)
Caspase-1 antibody
CASP-1 antibody
Interleukin-1 beta convertase antibody
IL-1BC antibody
Interleukin-1 beta-converting enzyme antibody
ICE antibody
IL-1 beta-converting enzyme antibody
p45 antibody
Caspase-1 subunit p20 antibody
Caspase-1 subunit p10 antibody
IL1BC antibody
IL1BCE antibody
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive .
Post-translational Modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Cellular Localization Cytoplasm.
Tissue Specificity Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Swiss-Prot Key P29466_HUMAN
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