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Anti-COL3A1 antibody

[STJ92388] Download PDF Print Data Sheet
Anti-COL3A1 antibody
5-7 days

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Product name Anti-COL3A1 antibody
Short Description Rabbit polyclonal to COL3A1.
Description COL3A1 is a protein encoded by the COL3A1 gene which is approximately 138,5 kDa. COL3A1 is secreted into the extracellular space and matrix. It is involved in collagen chain trimerization, integrin pathway, ERK signalling, phospholipase-C pathway and binding and uptake of ligands by scavenger receptors. It is involved in regulation of cortical development and is a major ligand of ADGRG1 in the developing brain. COL3A1 is expressed in skin, pancreas, bone, liver and lung. Mutations in the COL3A1 gene result in Ehlers-Danlos syndrome and thoracic aortic aneurysms. STJ92388 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of COL3A1 protein.
Applications ELISA, ICC, IF, IHC-p
Dilution range IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Specificity COL3A1 Polyclonal Antibody detects endogenous levels of COL3A1 protein.
Protein Name Collagen alpha-1
III chain
Immunogen Synthesized peptide derived from human COL3A1
Immunogen Region 50-130 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1281
Gene Symbol COL3A1
Molecular Weight 95 kDa
Database Links HGNC:2201
OMIM:120180
Alternative Names Collagen alpha-1 antibody
III chain antibody
Function Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Post-translational Modifications Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Cellular Localization Secreted, extracellular space, extracellular matrix
Sequence and Domain Family The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Swiss-Prot Key P02461_HUMAN
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