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Anti-DCAMKL2 antibody

[STJ92663] Download PDF Print Data Sheet
5-7 days

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Product name Anti-DCAMKL2 antibody
Short Description Rabbit polyclonal to DCAMKL2.
Description DCAMKL2 is a protein encoded by the DCLK2 gene which is approximately 83,6 kDa. DCAMKL2 is localised to the cytoplasm and is involved in transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. This protein falls under the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization. It also contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase. DCAMKL2 is expressed in the brain, heart and eye. The absence of this protein results in a severe epileptic phenotype and lethality. STJ92663 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of DCAMKL2 protein.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Specificity DCAMKL2 Polyclonal Antibody detects endogenous levels of DCAMKL2 protein.
Protein Name Serine/threonine-protein kinase DCLK2
CaMK-like CREB regulatory kinase 2
CL2
CLICK-II
CLICK2
Doublecortin domain-containing protein 3B
Doublecortin-like and CAM kinase-like 2
Doublecortin-like kinase 2
Immunogen Synthesized peptide derived from human DCAMKL2
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 166614
Gene Symbol DCLK2
Molecular Weight 83 kDa
Database Links HGNC:19002
OMIM:613166
Alternative Names Serine/threonine-protein kinase DCLK2 antibody
CaMK-like CREB regulatory kinase 2 antibody
CL2 antibody
CLICK-II antibody
CLICK2 antibody
Doublecortin domain-containing protein 3B antibody
Doublecortin-like and CAM kinase-like 2 antibody
Doublecortin-like kinase 2 antibody
DCDC3B antibody
DCK2 antibody
Function Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm .
Post-translational Modifications Autophosphorylated.
Cellular Localization Cytoplasm, cytoskeleton.. Colocalizes with microtubules.
Tissue Specificity Expressed in the brain, heart and eyes.
Sequence and Domain Family The doublecortin domains are involved in the colocalization with microtubules.
Swiss-Prot Key Q8N568_HUMAN
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