Anti-DNMT3A Antibody

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Product name Anti-DNMT3A Antibody
Short Description Rabbit monoclonal against DNMT3A
Description CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Applications IF, WB
Dilution range WB 1:500 - 1:2000
IF 1:100 - 1:500
Protein Name DNA
-methyltransferase 3A
Immunogen Recombinant protein of human DNMT3A
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IF
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 1788
Gene Symbol DNMT3A
Molecular Weight 101.858 kDa
Database Links HGNC:2978
Alternative Names DNA
-methyltransferase 3A
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development, DNA methylation is coordinated with methylation of histones, It modifies DNA in a non-processive manner and also methylates non-CpG sites, May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1, Plays a role in paternal and maternal imprinting, Required for methylation of most imprinted loci in germ cells, Acts as a transcriptional corepressor for ZBTB18, Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites, Can actively repress transcription through the recruitment of HDAC activity,
Post-translational Modifications Sumoylated
Cellular Localization Nucleus
Tissue Specificity Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung
Swiss-Prot Key Q9Y6K1
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