Anti-Endophilin I antibody

[STJ92924] Download PDF Print Data Sheet
Anti-Endophilin I antibody

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Product name Anti-Endophilin I antibody
Short Description Rabbit polyclonal to Endophilin I.
Description Endophilin I is a protein encoded by the SH3GL2 gene which is approximately 39,9 kDa. Endophilin I is localised to the cytoplasm and cell membrane. It is involved in clathrin derived vesicle budding, RET signalling and developmental biology. It function is in synaptic vesicle endocytosis. Endophilin I is expressed in the brain, mostly in the frontal cortex. Mutations in the SH3GL2 gene may result in childhood Pilocytic Astrocytoma. STJ92924 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Endophilin I protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:10000
Specificity Endophilin I Polyclonal Antibody detects endogenous levels of Endophilin I protein.
Protein Name Endophilin-A1
SH3 domain protein 2A
SH3 domain-containing GRB2-like protein 2
Immunogen Synthesized peptide derived from human Endophilin I
Immunogen Region 30-110 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6456
Gene Symbol SH3GL2
Molecular Weight 39 kDa
Database Links HGNC:10831
Alternative Names Endophilin-A1 antibody
EEN-B1 antibody
Endophilin-1 antibody
SH3 domain protein 2A antibody
SH3 domain-containing GRB2-like protein 2 antibody
CNSA2 antibody
SH3D2A antibody
Function Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Cellular Localization Cytoplasm Membrane Early endosome. Concentrated in presynaptic nerve terminals in neurons.
Tissue Specificity Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Sequence and Domain Family An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.
Swiss-Prot Key Q99962_HUMAN
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