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Anti-Enolase antibody

[STJ92926] Download PDF Print Data Sheet

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Product name Anti-Enolase antibody
Short Description Rabbit polyclonal to Enolase.
Description Enolase is a protein encoded by the ENO2 gene which is approximately 47,2 kDa. Enolase is localised to the cytoplasm and cell membrane and is involved in glucose metabolism, carbon metabolism, HIF-1 signalling pathway and de-adenylation-dependent mRNA decay. It is one of the three enolase isoenzymes found in mammals. It has neurotrophic and neuroprotective properties on number of central nervous system neurons. It binds to cultured neocortical neurons in the presence of calcium and promotes cell survival. The enolase alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. Mutations in the ENO2 gene can result in granular cell tumors, pediatric ovarian dysgerminoma and olfactory neuroblastoma. The antibody STJ92926 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Enolase protein.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Specificity Enolase Polyclonal Antibody detects endogenous levels of Enolase protein.
Protein Name Gamma-enolase
2-phospho-D-glycerate hydro-lyase
Enolase 2
Neural enolase
Neuron-specific enolase
NSE
Immunogen Synthesized peptide derived from human Enolase
Immunogen Region 340-420 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 2026
Gene Symbol ENO2
Molecular Weight 47 kDa
Database Links HGNC:3353
OMIM:131360
Alternative Names Gamma-enolase antibody
2-phospho-D-glycerate hydro-lyase antibody 2 antibody
Neural enolase antibody
Neuron-specific enolase antibody
NSE antibody
Function Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival .
Cellular Localization Cytoplasm Cell membrane. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.
Tissue Specificity The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
Swiss-Prot Key P09104_HUMAN
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