Anti-IL7R antibody (Alexa-fluor 647)

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Product name Anti-IL7R antibody (Alexa-fluor 647)
Short Description Mouse monoclonal against IL7R (Alexa-fluor 647)
Description The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)
Applications FC
Protein Name Low affinity immunoglobulin epsilon Fc receptor
BLAST-2
C-type lectin domain family 4 member J
Fc-epsilon-RII
Immunoglobulin E-binding factor
Lymphocyte IgE receptor
CD antigen CD23
Immunogen human leukemic pre-B cells
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application FC
Host Mouse
Clonality Monoclonal
Reactivity Canine, Human
Conjugation Alexa-fluor 647
Concentration 0.5 mg/ml
Purification QMA Hyper D ion exchange chromatography
Formulation PBS 50% glycerol
Gene ID 2208
Gene Symbol FCER2
Molecular Weight 36.469 kDa
Database Links HGNC:3612
OMIM:151445
Reactome:R-HSA-2197563
Alternative Names Low affinity immunoglobulin epsilon Fc receptor
BLAST-2
C-type lectin domain family 4 member J
Fc-epsilon-RII
Immunoglobulin E-binding factor
Lymphocyte IgE receptor
CD antigen CD23
Function Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Post-translational Modifications N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
Cellular Localization Cell membrane
Swiss-Prot Key P06734
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