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Anti-HSP60 antibody

[STJ93621] Download PDF Print Data Sheet
5-7 days

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Product name Anti-HSP60 antibody
Short Description Rabbit polyclonal to HSP60.
Description HSP60 is a protein encoded by the HSPD1 gene which is approximately 61 kDa. HSP60 is localised to the mitochondrion matrix and is involved in gene expression, transcriptional regulation, legionellosis and deadenylation-dependent mRNA decay. This protein falls under the chaperonin family. It is essential for the folding and assembly of newly imported proteins in the mitochondria. It also prevents misfolding and promote the refolding of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSP60 is expressed in liver, nervous system, blood, lung and skin. Mutations in the HSPD1 gene result in spastic paraplegia and leukodystrophy. STJ93621 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HSP60 protein.
Applications ELISA, IF, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Specificity HSP60 Polyclonal Antibody detects endogenous levels of HSP60 protein.
Protein Name 60 kDa heat shock protein, mitochondrial
60 kDa chaperonin
Chaperonin 60
CPN60
Heat shock protein 60
HSP-60
Hsp60
HuCHA60
Mitochondrial matrix protein P1
P60 lymphocyte protein
Immunogen Synthesized peptide derived from human HSP60
Immunogen Region 480-560 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3329
Gene Symbol HSPD1
Molecular Weight 68 kDa
Database Links HGNC:5261
OMIM:118190
Alternative Names 60 kDa heat shock protein, mitochondrial antibody
60 kDa chaperonin antibody
Chaperonin 60 antibody
CPN60 antibody
Heat shock protein 60 antibody
HSP-60 antibody
Hsp60 antibody
HuCHA60 antibody
Mitochondrial matrix protein P1 antibody
P60 lymphocyte protein antibody
Function Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix . The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).
Cellular Localization Mitochondrion matrix.
Swiss-Prot Key P10809_HUMAN
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