Anti-IL3RA antibody (Alexa-fluor 488)

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Product name Anti-IL3RA antibody (Alexa-fluor 488)
Short Description Mouse monoclonal to IL3RA (Alexa-fluor 488)
Description IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment
Applications FC, IF
Protein Name Interleukin-3 receptor subunit alpha
IL-3 receptor subunit alpha
IL-3R subunit alpha
IL-3R-alpha
IL-3RA
CD antigen CD123
Immunogen sorted human tonsillar pDC
Storage Instruction Store at -20◦C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application FC IF
Host Mouse
Clonality Monoclonal
Reactivity Canine, Human
Conjugation Alexa-fluor 488
Concentration 0.5 mg/ml
Purification QMA Hyper D ion exchange chromatography
Formulation PBS 50% glycerol
Gene ID 3563
Gene Symbol IL3RA
Molecular Weight 43.33 kDa
Database Links HGNC:6012
OMIM:308385
Reactome:R-HSA-114604
Alternative Names IL3RA (Alexa-fluor 488)
Interleukin-3 receptor subunit alpha antibody
IL-3 receptor subunit alpha antibody
IL-3R subunit alpha antibody
IL-3R-alpha antibody
IL-3RA antibody
CD antigen CD123 antibody
IL3R antibody
Function This is a receptor for interleukin-3.
Cellular Localization Membrane
Swiss-Prot Key P26951
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