Anti-Integrin alpha antibody

[STJ97284] Download PDF Print Data Sheet

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Product name Anti-Integrin alpha antibody
Short Description Rabbit polyclonal against Integrin alpha
Description Integrin alpha5 is a protein encoded by the ITGA5 gene which is approximately 114,5 kDa. Integrin alpha5 is localised to the cell membrane and is involved in the MAPK-Erk pathway, apoptotic pathways, integrin pathway, focal adhesion and blood-brain barrier and immune cell transmigration. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signalling. Integrin alpha5 is expressed in the liver, lung, nervous system, bone marrow and blood. Mutations in the ITGA5 gene may result in colon carcinoma and congenital epulis STJ97284 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Integrin alpha5 protein.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
Specificity Integrin alpha5 Polyclonal Antibody detects endogenous levels of Integrin alpha5 protein.
Protein Name Integrin alpha-5
CD49 antigen-like family member E
Fibronectin receptor subunit alpha
Integrin alpha-F
VLA-5
CD antigen CD49e
Integrin alpha-5 heavy chain
Integrin alpha-5 light chain
Immunogen Synthesized peptide derived from human Integrin alpha5.
Immunogen Region 561-610 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3678
Gene Symbol ITGA5
Database Links HGNC:6141
OMIM:135620
Alternative Names Integrin alpha-5
CD49 antigen-like family member E
Fibronectin receptor subunit alpha
Integrin alpha-F
VLA-5
CD antigen CD49e
Integrin alpha-5 heavy chain
Integrin alpha-5 light chain
Function Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 . (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for human metapneumovirus . Integrin ITGA2:ITGB1 acts as a receptor for human parvovirus B19 . In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions .
Post-translational Modifications Proteolytic cleavage by PCSK5 mediates activation of the precursor.
Cellular Localization Membrane. Single-pass type I membrane protein. Cell junction, focal adhesion Cell surface
Swiss-Prot Key P08648_HUMAN
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