Anti-KLK3 antibody

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Product name Anti-KLK3 antibody
Short Description Rabbit monoclonal against KLK3
Description Prostate-specific antigen (PSA) is a serine protease member of the human glandular kallikrein family. It is synthesized in the prostate ductal and acinar epithelium and diffused into serum. It is found in normal, hyperplastic, and malignant prostate tissue. Low expression of PSA has been reported in other normal or tumor tissues such as urethral, periurethral, and perianal glands, salivary duct carcinoma, and rare mammary carcinomas. Although low PSA expression has been found in other tissues, PSA is still a specific and sensitive marker for immunohistochemical analysis of tumors with prostate epithelial cell differentiation. It is valuable in the identification of metastatic tumors of prostatic origin.
Applications IHC
Dilution range 1:50-100
Protein Name Prostate-specific antigen
PSA
Immunogen Seminal fluid preparation
Storage Instruction Store at 2-8°C for up to 1 year
Note For Research Use Only (RUO).
Validated Application IHC
Host Rabbit
Clonality Monoclonal
Reactivity Human
Conjugation Unconjugated
Isotype IgG
Formulation Purified antibody in 0.2% BSA and 15mM sodium azide.
Gene ID 354
Gene Symbol KLK3
Molecular Weight 29 kDa
Database Links HGNC:6364
OMIM:176820
Reactome:R-HSA-381426
Alternative Names Prostate-specific antigen
PSA
Function Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum
Cellular Localization Secreted
Swiss-Prot Key P07288
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