Anti-LAMP3 antibody (Alexa-fluor 488)

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Product name Anti-LAMP3 antibody (Alexa-fluor 488)
Short Description Mouse monoclonal against LAMP3 (Alexa-fluor 488)
Description The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
Applications FC, IF
Protein Name Lysosome-associated membrane glycoprotein 3
LAMP-3
Lysosomal-associated membrane protein 3
DC-lysosome-associated membrane glycoprotein
DC LAMP
Protein TSC403
CD antigen CD208
Immunogen human DC-LAMP alkaline phosphatase fusion protein
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application FC IF
Host Mouse
Clonality Monoclonal
Reactivity Human, Sheep, Swine
Conjugation Alexa-fluor 488
Concentration 0.5 mg/ml
Purification QMA Hyper D ion exchange chromatography
Formulation PBS 50% glycerol
Gene ID 27074
Gene Symbol LAMP3
Molecular Weight 44.346 kDa
Database Links HGNC:14582
OMIM:605883
Alternative Names Lysosome-associated membrane glycoprotein 3
LAMP-3
Lysosomal-associated membrane protein 3
DC-lysosome-associated membrane glycoprotein
DC LAMP
Protein TSC403
CD antigen CD208
Function May play a role in dendritic cell function and in adaptive immunity.
Cellular Localization Lysosome membrane
Tissue Specificity Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
Swiss-Prot Key Q9UQV4
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