Anti-MAP2K2 Antibody

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Product name Anti-MAP2K2 Antibody
Short Description Rabbit polyclonal against MAP2K2
Description The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Dual specificity mitogen-activated protein kinase kinase 2
MAP kinase kinase 2
MAPKK 2
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP2K2 (NP_109587.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5605
Gene Symbol MAP2K2
Molecular Weight 44.424 kDa
Database Links HGNC:6842
OMIM:601263
Reactome:R-HSA-112411
Alternative Names Dual specificity mitogen-activated protein kinase kinase 2
MAP kinase kinase 2
MAPKK 2
Function Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases, Activates the ERK1 and ERK2 MAP kinases ,
Post-translational Modifications MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1), Phosphorylated by MAP2K1/MEK1 ,
Cellular Localization Cytoplasm
Swiss-Prot Key P36507
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