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Anti-Met antibody

[STJ94103] Download PDF Print Data Sheet
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Product name Anti-Met antibody
Description Rabbit polyclonal to Met.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Specificity Met Polyclonal Antibody detects endogenous levels of Met protein.
Protein Name Hepatocyte growth factor receptor
HGF receptor
HGF/SF receptor
Proto-oncogene c-Met
Scatter factor receptor
SF receptor
Tyrosine-protein kinase Met
Immunogen Synthesized peptide derived from human Met around the non-phosphorylation site of Y1349.
Immunogen Region 1290-1370 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4233
Gene Symbol MET
Molecular Weight 145 kDa
Database Links HGNC:7029
OMIM:114550
Alternative Names Met
Hepatocyte growth factor receptor antibody
HGF receptor antibody
HGF/SF receptor antibody
Proto-oncogene c-Met antibody
Scatter factor receptor antibody
SF receptor antibody
Tyrosine-protein kinase Met antibody
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis . Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Post-translational Modifications Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2. Ubiquitinated. Ubiquitination by CBL regulates MET endocytosis, resulting in decreasing plasma membrane receptor abundance, and in endosomal degradation and/or recycling of internalized receptors.
Cellular Localization Membrane; Single-pass type I membrane protein.; Isoform 3: Secreted.
Tissue Specificity Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) .
Sequence and Domain Family The kinase domain is involved in SPSB1 binding.; The beta-propeller Sema domain mediates binding to HGF.
Swiss-Prot Key P08581_HUMAN
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