Anti-MonoMethyl-Histone antibody

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Product name Anti-MonoMethyl-Histone antibody
Short Description Rabbit h4-k20 to MonoMethyl-Histone
Description Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
Applications ChIP, IF, IHC, IP, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
ChIP 1:20 - 1:100
CHIPseq 1:20 - 1:100
Protein Name Histone H4
Immunogen A synthetic peptide of human MonoMethyl-Histone H4-K20
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF IP ChIP
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 121504
Gene Symbol HIST1H4A
Molecular Weight 11.367 kDa
Database Links HGNC:4781
OMIM:142750
Reactome:R-HSA-1221632
Alternative Names MonoMethyl-Histone
Histone H4 antibody
H4/A antibody
H4FA; antibody
HIST1H4B antibody
H4/I antibody
H4FI; antibody
HIST1H4C antibody
H4/G antibody
H4FG; antibody
HIST1H4D antibody
H4/B antibody
H4FB; antibody
HIST1H4E antibody
H4/J antibody
H4FJ; antibody
HIST1H4F antibody
H4/C antibody
H4FC; antibody
HIST1H4H antibody
H4/H antibody
H4FH; antibody
HIST1H4I antibody
H4/M antibody
H4FM; antibody
HIST1H4J antibody
H4/E antibody
H4FE; antibody
HIST1H4K antibody
H4/D antibody
H4FD; antibody
HIST1H4L antibody
H4/K antibody
H4FK; antibody
HIST2H4A antibody
H4/N antibody
H4F2 antibody
H4FN antibody
HIST2H4; antibody
HIST2H4B antibody
H4/O antibody
H4FO; antibody
HIST4H4 antibody
Function Core component of nucleosome, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Post-translational Modifications Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin,
Cellular Localization Nucleus, Chromosome
Swiss-Prot Key P62805
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