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Anti-MRE11 antibody

[STJ94194] Download PDF Print Data Sheet
5-7 days

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Product name Anti-MRE11 antibody
Short Description Rabbit polyclonal to MRE11.
Description MRE11 is a protein encoded by the MRE11 gene which is approximately 80,5 kDa. MRE11 is localised to the nucleus and is involved in DNA double-strand break repair, cytosolic sensors of pathogen-associated DNA and telomere length maintenance. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. In conjunction with a DNA ligase, it promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. MRE11 is expressed in the nervous system, liver and blood. Mutations in the MRE11 gene may result in ataxia-telangiectasia-like disorder, Nijmegen breakage syndrome and hereditary breast ovarian cancer. STJ94194 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MRE11 protein.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Specificity MRE11 Polyclonal Antibody detects endogenous levels of MRE11 protein.
Protein Name Double-strand break repair protein MRE11
Double-strand break repair protein MRE11A
Meiotic recombination 11 homolog 1
MRE11 homolog 1
Meiotic recombination 11 homolog A
MRE11 homolog A
Immunogen Synthesized peptide derived from human MRE11 around the non-phosphorylation site of S264.
Immunogen Region 200-280 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Monkey, Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4361
Gene Symbol MRE11
Molecular Weight 80 kDa
Database Links HGNC:7230
OMIM:600814
Alternative Names Double-strand break repair protein MRE11 antibody
Double-strand break repair protein MRE11A antibody
Meiotic recombination 11 homolog 1 antibody homolog 1 antibody
Meiotic recombination 11 homolog A antibody homolog A antibody
HNGS1 antibodyA antibody
Swiss-Prot Key P49959_HUMAN
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