Anti-MYC Antibody

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Product name Anti-MYC Antibody
Short Description Rabbit polyclonal against MYC
Description The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Applications ChIP, IP, WB
Dilution range WB 1:500 - 1:1000
IP 1:50 - 1:100
ChIP 1:20 - 1:50
Protein Name Myc proto-oncogene protein
Class E basic helix-loop-helix protein 39
bHLHe39
Proto-oncogene c-Myc
Transcription factor p64
Immunogen Recombinant protein of human MYC
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IP ChIP
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 4609
Gene Symbol MYC
Molecular Weight 48.804 kDa
Database Links HGNC:7553
OMIM:113970
Reactome:R-HSA-1362277
Alternative Names Myc proto-oncogene protein
Class E basic helix-loop-helix protein 39
bHLHe39
Proto-oncogene c-Myc
Transcription factor p64
Function Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3', Activates the transcription of growth-related genes, Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis ,
Post-translational Modifications Phosphorylated by PRKDC, Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC , Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence, Phosphorylated at Ser-62 by DYRK2
Cellular Localization Nucleus, nucleoplasm
Swiss-Prot Key P01106
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