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Anti-Neuregulin-1 SMDF antibody

[STJ94419] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Neuregulin-1 SMDF antibody
Short Description Rabbit polyclonal to Neuregulin-1 SMDF.
Description Neuregulin-1 SMDF is a protein encoded by the NRG1 gene which is approximately 70,3 kDa. Neuregulin-1 SMDF is secreted and some isoforms are localised to the nucleus. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts, GAB1 signalosome and the GPCR pathway. It mediates cell-cell signalling and plays a critical role in the growth and development of multiple organ systems. It is also a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Neuregulin-1 SMDF isoform type 1 is the predominant form expressed in the endocardium. Mutations in the NRG1 gene may result in schizophrenia and bipolar disorder. STJ94419 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neuregulin-1 SMDF protein.
Applications ELISA, IF, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Specificity Neuregulin-1 SMDF Polyclonal Antibody detects endogenous levels of Neuregulin-1 SMDF protein.
Protein Name Pro-neuregulin-1, membrane-bound isoform
Pro-NRG1
Neuregulin-1
Acetylcholine receptor-inducing activity
ARIA
Breast cancer cell differentiation factor p45
Glial growth factor
Heregulin
HRG
Neu differentiation factor
Sensory and motor neuron-derived factor
Immunogen Synthesized peptide derived from human Neuregulin-1 SMDF
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Symbol NRG1
Molecular Weight 44 kDa
Alternative Names Neuregulin-1 SMDF
Pro-neuregulin-1, membrane-bound isoform antibody
Pro-NRG1 antibody
Neuregulin-1 antibody
Acetylcholine receptor-inducing activity antibody
ARIA antibody
Breast cancer cell differentiation factor p45 antibody
Glial growth factor antibody
Heregulin antibody
HRG antibody
Neu differentiation factor antibody
Sensory and motor neuron-derived factor antibody
GGF antibody
HGL antibody
HRGA antibody
NDF antibody
SMDF antibody
Function Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 . Binds to ERBB3 . Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 . Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons .
Post-translational Modifications Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.; N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage .
Cellular Localization Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein.. Does not seem to be active.; Neuregulin-1: Secreted.; Isoform 8: Nucleus.. May be nuclear.; Isoform 9: Secreted.. Has a signal peptide.; Isoform 10: Membrane; Single-pass type I membrane protein.. May possess an internal uncleaved signal sequence.
Tissue Specificity Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cell
Sequence and Domain Family The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization . ERBB receptor binding is elicited entirely by the EGF-like domain.
Swiss-Prot Key Q02297_HUMAN
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