Anti-NOX4 Antibody

[STJ113449] Download PDF Print Data Sheet

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Product name Anti-NOX4 Antibody
Short Description Rabbit monoclonal against NOX4
Description This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
Applications FC, IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
ICC 1:50 - 1:200
IF 1:50 - 1:100
Protein Name NADPH oxidase 4
Immunogen Recombinant protein of human NOX4
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC ICC IF
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 50507
Gene Symbol NOX4
Molecular Weight 66.932 kDa
Database Links HGNC:7891
OMIM:605261
Reactome:R-HSA-3299685
Alternative Names NADPH oxidase 4
Function Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox, Regulates signaling cascades probably through phosphatases inhibition, May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity, May regulate insulin signaling cascade, May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB, May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation, Isoform 3 is not functional, Isoform 5 and isoform 6 display reduced activity
Post-translational Modifications Isoform 3 and isoform 4 are N-glycosylated, Isoform 4 glycosylation is required for its proper function,
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level), Widely expressed, Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells
Swiss-Prot Key Q9NPH5
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