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Anti-NPAS4 antibody

[STJ94544] Download PDF Print Data Sheet

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Product name Anti-NPAS4 antibody
Description Rabbit polyclonal to NPAS4.
Applications ELISA, IHC
Dilution range IHC 1:100-1:300
ELISA 1:20000
Specificity NPAS4 Polyclonal Antibody detects endogenous levels of NPAS4 protein.
Protein Name Neuronal PAS domain-containing protein 4
Neuronal PAS4
Class E basic helix-loop-helix protein 79
bHLHe79
HLH-PAS transcription factor NXF
PAS domain-containing protein 10
Immunogen Synthesized peptide derived from human NPAS4
Immunogen Region 580-660 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 266743
Gene Symbol NPAS4
Molecular Weight 87.117 kDa
Database Links HGNC:18983
OMIM:608554
Alternative Names Neuronal PAS domain-containing protein 4 antibody
Neuronal PAS4 antibody
Class E basic helix-loop-helix protein 79 antibody
bHLHe79 antibody
HLH-PAS transcription factor NXF antibody
PAS domain-containing protein 10 antibody
BHLHE79 antibody
NXF antibody
PASD10 antibody
Function Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus . Plays a key role in the structural and functional plasticity of neurons . Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience . In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons . In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits . The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior . Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 . Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 . Can activate the CME (CNS midline enhancer) element .
Post-translational Modifications Ubiquitinated, leading to degradation by the proteosome.
Cellular Localization Nucleus
Tissue Specificity Brain.
Swiss-Prot Key Q8IUM7_HUMAN
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