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Anti-p63 antibody

[STJ94912] Download PDF Print Data Sheet
Anti-p63 antibody
5-7 days

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Product name Anti-p63 antibody
Short Description Rabbit polyclonal to p63.
Description P63 is a protein encoded by the TP63 gene which is approximately 76,8 kDa. P63 is localised to the nucleus and is involved in the regulation of transcription of cell death genes, activation of BH3-only proteins, regulation of TP53 activity and gene expression. This protein falls under the p53 family of transcription factors. p63 acts as a sequence specific DNA binding transcriptional activator or repressor. By interacting with TP73/p73 it may also be required for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is expressed in the skin, muscle, blood and lungs. Mutations in the TP63 gene can result in ectrodactyly and Rap-Hodgkin syndrome. STJ94912 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p63 protein.
Applications ELISA, IF, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Specificity p63 Polyclonal Antibody detects endogenous levels of p63 protein.
Protein Name Tumor protein 63
p63
Chronic ulcerative stomatitis protein
CUSP
Keratinocyte transcription factor KET
Transformation-related protein 63
TP63
Tumor protein p73-like
p73L
p40
p51
Immunogen Synthesized peptide derived from human p63
Immunogen Region 600-680 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Monkey, Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8626
Gene Symbol TP63
Molecular Weight 77 kDa
Database Links HGNC:15979
OMIM:103285
Alternative Names p63
Tumor protein 63 antibody
p63 antibody
Chronic ulcerative stomatitis protein antibody
CUSP antibody
Keratinocyte transcription factor KET antibody
Transformation-related protein 63 antibody
Tumor protein p73-like antibody
p73L antibody
p40 antibody
p51 antibody
KET antibody
P63 antibody
P73H antibody
P73L antibody
TP73L antibody
Function Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Post-translational Modifications May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Cellular Localization Nucleus
Tissue Specificity Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Sequence and Domain Family The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.
Swiss-Prot Key Q9H3D4_HUMAN
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