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Anti-Phospho-Axl (Y691) antibody

[STJ90939] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Phospho-Axl (Y691) antibody
Short Description Rabbit polyclonal to Phospho-Axl (Y691).
Description Axl is a protein encoded by the AXL gene which is approximately 98,3 kDa. Axl is localised to the cell membrane. It is involved in the GPCR pathway, ERK signalling, actin nucleation by ARP-WASP complex and activation of cAMP-dependent PKA. This protein falls under the Tyro3-Axl-Mer receptor tyrosine kinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6. Axl is expressed in primary colon tumors but weakly expressed in normal colon tissue. Mutations in the AXL gene may result in lymphocytic choriomeningitis, femoral neuropathy and Borna disease. STJ90939 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Axl protein which only binds about Y691 when Y691 is phosphorylated.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Specificity Phospho-Axl (Y691) Polyclonal Antibody detects endogenous levels of Axl protein only when phosphorylated at Y691.
Protein Name Tyrosine-protein kinase receptor UFO
AXL oncogene
Immunogen Synthesized peptide derived from human Axl around the phosphorylation site of Y691.
Immunogen Region 630-710 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 558
Gene Symbol AXL
Molecular Weight 110/97 kDa
Database Links HGNC:905
OMIM:109135
Alternative Names Phospho-Axl (Y691)
Tyrosine-protein kinase receptor UFO antibody oncogene antibody
UFO antibody
Swiss-Prot Key P30530_HUMAN
Bad Good
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