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Anti-Phospho-CRMP-2 (T509) antibody

[STJ90974] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Phospho-CRMP-2 (T509) antibody
Short Description Rabbit polyclonal to Phospho-CRMP-2 (T509).
Description CRMP-2 is a protein encoded by the DPYSL2 gene which is approximately 62,2 kDa. CRMP-2 is localised to the cytoplasm and cytosol. It is involved in developmental biology, semaphorin interactions, development slit-robo signalling, axon guidance and cytoskeletal signalling. This protein falls under the collapsin response mediator protein family. It plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. CRMP-2 is ubiquitously expressed. Mutations in the DPYSL2 gene may result in Alzheimer disease. STJ90974 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This primary antibody specifically binds to endogenous CRMP-2 protein which only binds about T509 when T509 is phosphorylated.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Specificity Phospho-CRMP-2 (T509) Polyclonal Antibody detects endogenous levels of CRMP-2 protein only when phosphorylated at T509.
Protein Name Dihydropyrimidinase-related protein 2
DRP-2
Collapsin response mediator protein 2
CRMP-2
N2A3
Unc-33-like phosphoprotein 2
ULIP-2
Immunogen Synthesized peptide derived from human CRMP-2 around the phosphorylation site of T509.
Immunogen Region 450-530 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1808
Gene Symbol DPYSL2
Molecular Weight 50 kDa
Database Links HGNC:3014
OMIM:602463
Alternative Names Phospho-CRMP-2 (T509)
Dihydropyrimidinase-related protein 2 antibody
DRP-2 antibody
Collapsin response mediator protein 2 antibody
CRMP-2 antibody
N2A3 antibody
Unc-33-like phosphoprotein 2 antibody
ULIP-2 antibody
CRMP2 antibody
ULIP2 antibody
Function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Post-translational Modifications 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration . Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
Cellular Localization Cytoplasm, cytosol Cytoplasm, cytoskeleton Membrane. Tightly but non-covalently associated with membranes.
Tissue Specificity Ubiquitous.
Swiss-Prot Key Q16555_HUMAN
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