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Anti-Phospho-RUNX1 (S249) antibody

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Product name Anti-Phospho-RUNX1 (S249) antibody
Description Rabbit polyclonal to Phospho-RUNX1 (S249).
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:5000
Specificity Phospho-RUNX1 (S249) Polyclonal Antibody detects endogenous levels of RUNX1 protein only when phosphorylated at S249.
Protein Name Runt-related transcription factor 1
Acute myeloid leukemia 1 protein
Core-binding factor subunit alpha-2
CBF-alpha-2
Oncogene AML-1
Polyomavirus enhancer-binding protein 2 alpha B subunit
PEA2-alpha B
PEBP2-alpha B
SL3-3 enhancer factor 1 alpha B subunit
SL3/AKV core-binding factor alpha B subunit
Immunogen Synthesized peptide derived from human RUNX1 around the phosphorylation site of S249.
Immunogen Region 220-300 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 861
Gene Symbol RUNX1
Molecular Weight 49 kDa
Database Links HGNC:10471
OMIM:151385
Alternative Names Phospho-RUNX1 (S249)
Runt-related transcription factor 1 antibody
Acute myeloid leukemia 1 protein antibody
Core-binding factor subunit alpha-2 antibody
CBF-alpha-2 antibody
Oncogene AML-1 antibody
Polyomavirus enhancer-binding protein 2 alpha B subunit antibody
PEA2-alpha B antibody
PEBP2-alpha B antibody
SL3-3 enhancer factor 1 alpha B subunit antibody
SL3/AKV core-binding factor alpha B subunit antibody
AML1 antibody
CBFA2 antibody
Function CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells .
Post-translational Modifications Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.; Methylated. Phosphorylated in Ser-249 Thr-273 and Ser-276 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation.
Cellular Localization Nucleus.
Tissue Specificity Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Sequence and Domain Family A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
Swiss-Prot Key Q01196_HUMAN
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