Anti-PIK3CB Antibody

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Product name Anti-PIK3CB Antibody
Short Description Rabbit monoclonal against PIK3CB
Description This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K).
These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of
the activation pathway in neutrophils which have bound
immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants.
Applications FC, IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
ICC 1:50 - 1:200
IF 1:50 - 1:100
FC 1:20 - 1:50
Protein Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
PI3-kinase subunit beta
PI3K-beta
PI3Kbeta
PtdIns-3-kinase subunit beta
Immunogen Recombinant protein of human PIK3CB
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5291
Gene Symbol PIK3CB
Molecular Weight 122.762 kDa
Database Links HGNC:8976
OMIM:602925
Reactome:R-HSA-109704
Alternative Names Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
PI3-kinase subunit beta
PI3K-beta
PI3Kbeta
PtdIns-3-kinase subunit beta
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology, Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid, May also act downstream receptor tyrosine kinases, Required in different signaling pathways for stable platelet adhesion and aggregation, Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6, Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces, Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2), Has a role in cell survival, May have a role in cell migration, Involved in the early stage of autophagosome formation, Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity, May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy, May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required, May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis, Mediator of oncogenic signal in cell lines lacking PTEN, The lipid kinase activity is necessary for its role in oncogenic transformation, Required for the growth of ERBB2 and RAS driven tumors,
Post-translational Modifications Phosphorylation at Ser-1070 down-regulates lipid kinase activity,
Cellular Localization Cytoplasm,
Tissue Specificity Expressed ubiquitously
Swiss-Prot Key P42338
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