Anti-PXR antibody

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Anti-PXR antibody

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Product name Anti-PXR antibody
Description Rabbit polyclonal to PXR.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:40000
Specificity PXR Polyclonal Antibody detects endogenous levels of PXR protein.
Protein Name Nuclear receptor subfamily 1 group I member 2
Orphan nuclear receptor PAR1
Orphan nuclear receptor PXR
Pregnane X receptor
Steroid and xenobiotic receptor
Immunogen Synthesized peptide derived from human PXR
Immunogen Region 60-140 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8856
Gene Symbol NR1I2
Molecular Weight 50 kDa
Database Links HGNC:7968
Alternative Names PXR
Nuclear receptor subfamily 1 group I member 2 antibody
Orphan nuclear receptor PAR1 antibody
Orphan nuclear receptor PXR antibody
Pregnane X receptor antibody
Steroid and xenobiotic receptor antibody
SXR antibody
PXR antibody
Function Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Cellular Localization Nucleus
Tissue Specificity Expressed in liver, colon and small intestine.
Swiss-Prot Key O75469_HUMAN
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