Anti-RAB27A Antibody

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Product name Anti-RAB27A Antibody
Short Description Rabbit polyclonal against RAB27A
Description The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
Applications IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100
Protein Name Ras-related protein Rab-27A
GTP-binding protein Ram
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human RAB27A (NP_899057.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5873
Gene Symbol RAB27A
Molecular Weight 24.868 kDa
Database Links HGNC:9766
Alternative Names Ras-related protein Rab-27A
GTP-binding protein Ram
Function Plays a role in cytotoxic granule exocytosis in lymphocytes, Required for both granule maturation and granule docking and priming at the immunologic synapse,
Cellular Localization Membrane,
Tissue Specificity Found in all the examined tissues except in brain, Low expression was found in thymus, kidney, muscle and placenta, Detected in melanocytes, and in most tumor cell lines examined, Expressed in cytotoxic T-lymphocytes (CTL) and mast cells
Swiss-Prot Key P51159
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