Anti-RBBP4 Antibody

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Product name Anti-RBBP4 Antibody
Short Description Rabbit polyclonal against RBBP4
Description This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.
Applications ChIP, IF, WB
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
ChIP 1:20 - 1:50
Protein Name Histone-binding protein RBBP4
Chromatin assembly factor 1 subunit C
CAF-1 subunit C
Chromatin assembly factor I p48 subunit
CAF-I 48 kDa subunit
CAF-I p48
Nucleosome-remodeling factor subunit RBAP48
Retinoblastoma
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-425 of human RBBP4 (NP_005601.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IF ChIP
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5928
Gene Symbol RBBP4
Molecular Weight 47.656 kDa
Database Links HGNC:9887
OMIM:602923
Reactome:R-HSA-1362277
Alternative Names Histone-binding protein RBBP4
Chromatin assembly factor 1 subunit C
CAF-1 subunit C
Chromatin assembly factor I p48 subunit
CAF-I 48 kDa subunit
CAF-I p48
Nucleosome-remodeling factor subunit RBAP48
Retinoblastoma
Function Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA, Component of several complexes which regulate chromatin metabolism, These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair
Cellular Localization Nucleus
Swiss-Prot Key Q09028
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