Anti-RBBP7 Antibody

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Product name Anti-RBBP7 Antibody
Short Description Rabbit polyclonal to RBBP7
Description This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
Applications ChIP, IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
ChIP 1:50 - 1:200
Protein Name Histone-binding protein RBBP7
Histone acetyltransferase type B subunit 2
Nucleosome-remodeling factor subunit RBAP46
Retinoblastoma-binding protein 7
RBBP-7
Retinoblastoma-binding protein p46
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RBBP7 (NP_002884.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF ChIP
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5931
Gene Symbol RBBP7
Molecular Weight 47.82 kDa
Database Links HGNC:9890
OMIM:300825
Reactome:R-HSA-212300
Alternative Names Histone-binding protein RBBP7
Histone acetyltransferase type B subunit 2
Nucleosome-remodeling factor subunit RBAP46
Retinoblastoma-binding protein 7
RBBP-7
Retinoblastoma-binding protein p46
Function Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA, Component of several complexes which regulate chromatin metabolism, These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication
Cellular Localization Nucleus
Swiss-Prot Key Q16576
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