Anti-RBFOX3 Antibody

[STJ113146] Download PDF Print Data Sheet

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Product name Anti-RBFOX3 Antibody
Short Description Rabbit monoclonal against RBFOX3
Description This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Applications IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:500
IF 1:50 - 1:200
Protein Name RNA binding protein fox-1 homolog 3
Fox-1 homolog C
Neuronal nuclei antigen
NeuN antigen
Immunogen Recombinant protein of human RBFOX3
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 146713
Gene Symbol RBFOX3
Molecular Weight 33.873 kDa
Database Links HGNC:27097
Alternative Names RNA binding protein fox-1 homolog 3
Fox-1 homolog C
Neuronal nuclei antigen
NeuN antigen
Function Pre-mRNA alternative splicing regulator, Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD),
Cellular Localization Nucleus
Swiss-Prot Key A6NFN3
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