Anti-SALL4 antibody

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Product name Anti-SALL4 antibody
Short Description Rabbit monoclonal to SALL4
Description SALL4 is a zinc finger transcription factor. Anti-SALL4 demonstrates 100% sensitivity and stains more than 90% tumor cells in all intratubular germ cell neoplasia, seminomas/ dysgerminomas, embryonal carcinomas, and yolk sac tumor (YST). Anti-SALL4 also stains most cases of teratoma and the mononucleated trophoblastic cells in choriocarcinomas. In contrast, non-germ cell tumors show no anti- SALL4 staining. Most non- testicular tumors from various organs and sites are negative for anti-SALL4, though an occasional carcinoma or sarcoma may show weak anti-SALL4 staining in less than 25% of tumor cells except hepatocellular carcinoma (HCC). In HCC, anti-SALL4 staining shows a intranuclear granular pattern.
Applications IHC
Dilution range 1:50-100
Protein Name Sal-like protein 4
Zinc finger protein 797
Zinc finger protein SALL4
Immunogen Recombinant fragment corresponding to amino acids 954-1054 of Human Sall4
Storage Instruction Store at 2-8°C for up to 1 year
Note For Research Use Only (RUO).
Validated Application IHC
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Isotype IgG
Formulation Purified antibody in 0.2% BSA and 15mM sodium azide.
Gene ID 57167
Gene Symbol SALL4
Molecular Weight 112 kDa
Database Links HGNC:15924
OMIM:147750
Reactome:R-HSA-2892247
Alternative Names Sal-like protein 4
Zinc finger protein 797
Zinc finger protein SALL4
Function Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells,
Post-translational Modifications Isoform SALL4B exists primarily as a ubiquitinated form.
Cellular Localization Cytoplasm, Nucleus
Tissue Specificity Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML).
Swiss-Prot Key Q9UJQ4
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