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Anti-Stat2 antibody

[STJ96415] Download PDF Print Data Sheet

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Product name Anti-Stat2 antibody
Description Rabbit polyclonal to Stat2.
Applications ELISA, IHC, WB
Dilution range WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:10000
Specificity Stat2 Polyclonal Antibody detects endogenous levels of Stat2 protein.
Protein Name Signal transducer and activator of transcription 2
p113
Immunogen Synthesized peptide derived from human Stat2 around the non-phosphorylation site of Y631.
Immunogen Region 570-650 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6773
Gene Symbol STAT2
Molecular Weight 113 kDa
Database Links HGNC:11363
OMIM:600556
Alternative Names Stat2
Signal transducer and activator of transcription 2 antibody
p113 antibody
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state . Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively .
Post-translational Modifications Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.
Cellular Localization Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Swiss-Prot Key P52630_HUMAN
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