Anti-SUMO-1 antibody

[STJ95835] Download PDF Print Data Sheet

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Product name Anti-SUMO-1 antibody
Short Description Rabbit polyclonal to SUMO-1.
Description SUMO-1 is a protein encoded by the SUMO1 gene which is approximately 11,6 kDa. SUMO-1 is localised to the nuclear membrane and nucelus. It is involved in SUMOylation, DNA double-strand break repair, transcription-coupled nucleotide excision repair and interferon gamma signalling. This protein falls under the SUMO protein family. It functions similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. This protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO-1 is expressed in the cells of the nervous system, liver, lung, kidney and blood. Mutations in the SUMO1 gene result in disease such as non-syndromic orofacial cleft 10 which is a birth defect exhibiting cleft lips which can range in severity and can occur on one or both sides. TJ95835 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody binds endogenous SUMO-1.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Specificity SUMO-1 Polyclonal Antibody detects endogenous levels of SUMO-1 protein.
Protein Name Small ubiquitin-related modifier 1
GAP-modifying protein 1
SMT3 homolog 3
Ubiquitin-homology domain protein PIC1
Ubiquitin-like protein SMT3C
Ubiquitin-like protein UBL1
Immunogen Synthesized peptide derived from human SUMO-1
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7341
Gene Symbol SUMO1
Molecular Weight 12 kDa
Database Links HGNC:12502
Alternative Names SUMO-1
Small ubiquitin-related modifier 1 antibody
SUMO-1 antibody
GAP-modifying protein 1 antibody
GMP1 antibody
SMT3 homolog 3 antibody
Sentrin antibody
Ubiquitin-homology domain protein PIC1 antibody
Ubiquitin-like protein SMT3C antibody
Smt3C antibody
Ubiquitin-like protein UBL1 antibody
SMT3C antibody
SMT3H3 antibody
UBL1 antibody
OK/SW-cl.43 antibody
Function Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 . Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 .
Post-translational Modifications Cleavage of precursor form by SENP1 or SENP2 is necessary for function.; Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
Cellular Localization Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane Nucleus. Recruited by BCL11A into the nuclear body. In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.
Swiss-Prot Key P63165_HUMAN
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