Anti-TEAD1 Antibody

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Product name Anti-TEAD1 Antibody
Short Description Rabbit polyclonal against TEAD1
Description This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified.
Applications ChIP, IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
CHIP 1:20 - 1:50
Protein Name Transcriptional enhancer factor TEF-1
Protein GT-IIC
TEA domain family member 1
Transcription factor 13
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 135-215 of human TEAD1 (NP_068780.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF ChIP
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 7003
Gene Symbol TEAD1
Molecular Weight 47.946 kDa
Database Links HGNC:11714
Alternative Names Transcriptional enhancer factor TEF-1
Protein GT-IIC
TEA domain family member 1
Transcription factor 13
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction, Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner, The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF), Involved in cardiac development, Binds to the M-CAT motif,
Cellular Localization Nucleus
Tissue Specificity Preferentially expressed in skeletal muscle, Lower levels in pancreas, placenta, and heart
Swiss-Prot Key P28347
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