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Anti-Tom20 antibody

[STJ96061] Download PDF Print Data Sheet

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Product name Anti-Tom20 antibody
Short Description Rabbit polyclonal to Tom20.
Description Tom20 is a protein encoded by the TOMM20 gene which is approximately 16,2 kDa. Tom20 is localised to the mitochondrion outer membrane and is involved in deubiquitination, metabolism of proteins, pink/parkin mediated mitophagy, and glucose / energy metabolism. It is a central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Tom20 is expressed in the nervous system, bone marrow, pancreas, eye and liver. Mutations in the TOMM20 gene result in Perry syndrome and infantile neuroaxonal dystrophy. STJ96061 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Tom20 protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:40000
Specificity Tom20 Polyclonal Antibody detects endogenous levels of Tom20 protein.
Protein Name Mitochondrial import receptor subunit TOM20 homolog
Mitochondrial 20 kDa outer membrane protein
Outer mitochondrial membrane receptor Tom20
Immunogen Synthesized peptide derived from human Tom20
Immunogen Region 30-110 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 9804
Gene Symbol TOMM20
Molecular Weight 17 kDa
Database Links HGNC:20947
OMIM:601848
Alternative Names Tom20
Mitochondrial import receptor subunit TOM20 homolog antibody
Mitochondrial 20 kDa outer membrane protein antibody
Outer mitochondrial membrane receptor Tom20 antibody
KIAA0016 antibody
Function Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore .
Post-translational Modifications Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Cellular Localization Mitochondrion outer membrane
Swiss-Prot Key Q15388_HUMAN
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