Anti-TriMethylH3K56me3-(K56) Antibody

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Product name Anti-TriMethylH3K56me3-(K56) Antibody
Short Description Rabbit Polyclonal to TriMethylH3K56me3(K56)
Description Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
Applications ChIP, IF, IHC, IP, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
ChIP 1:20 - 1:100
CHIPseq 1:20 - 1:100
Protein Name Histone H3.1t
H3/t
H3t
H3/g
Immunogen A synthetic peptide of human TriMethyl-Histone H3-K56
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF IP ChIP
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 8290
Gene Symbol HIST3H3
Molecular Weight 15.508 kDa
Database Links HGNC:4778
OMIM:602820
Reactome:R-HSA-1221632
Alternative Names Histone H3.1t
H3/t
H3t
H3/g
Function Core component of nucleosome, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Post-translational Modifications Acetylation is generally linked to gene activation, Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s), Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me), Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability ,
Cellular Localization Nucleus, Chromosome
Tissue Specificity Expressed in testicular cells
Swiss-Prot Key Q16695
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