Anti-TSPO Antibody

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Product name Anti-TSPO Antibody
Short Description Rabbit monoclonal to TSPO
Description Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
Applications IF, IHC, IP, WB
Dilution range WB 1:5000 - 1:10000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:20 - 1:50
Protein Name Translocator protein
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
PBR
Immunogen Recombinant protein of human TSPO
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF IP
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 706
Gene Symbol TSPO
Molecular Weight 18.828 kDa
Database Links HGNC:1158
OMIM:109610
Reactome:R-HSA-196108
Alternative Names Translocator protein
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
PBR
Function Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme , Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism ,
Cellular Localization Mitochondrion membrane
Tissue Specificity Found in many tissue types, Expressed at the highest levels under normal conditions in tissues that synthesize steroids
Swiss-Prot Key P30536
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