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Anti-V-ATPase B1 antibody

[STJ96223] Download PDF Print Data Sheet
5-7 days

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Product name Anti-V-ATPase B1 antibody
Short Description Rabbit polyclonal to V-ATPase B1.
Description V-ATPase B1 is a protein encoded by the ATP6V1B1 gene which is approximately 56,8 kDa. V-ATPase B1 is localised to the endomembrane system. It is involved in insulin receptor recycling, innate immune system, metabolism and mTOR signalling pathway. It mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase B1 is expressed in the cochlea and endolymphatic sac. Mutations in the ATP6V1B1 gene may result in renal tubular acidosis with progressive nerve deafness. STJ96223 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of V-ATPase B1 protein.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Specificity V-ATPase B1 Polyclonal Antibody detects endogenous levels of V-ATPase B1 protein.
Protein Name V-type proton ATPase subunit B, kidney isoform
V-ATPase subunit B 1
Endomembrane proton pump 58 kDa subunit
Vacuolar proton pump subunit B 1
Immunogen Synthesized peptide derived from human V-ATPase B1
Immunogen Region 350-430 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 525
Gene Symbol ATP6V1B1
Molecular Weight 60 kDa
Database Links HGNC:853
OMIM:192132
Alternative Names V-ATPase B1
V-type proton ATPase subunit B, kidney isoform antibody
V-ATPase subunit B 1 antibody
Endomembrane proton pump 58 kDa subunit antibody
Vacuolar proton pump subunit B 1 antibody
ATP6B1 antibody
VATB antibody
VPP3 antibody
Function Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Cellular Localization Endomembrane system; Peripheral membrane protein.. Endomembrane.
Tissue Specificity Expressed in the cochlea and endolymphatic sac.
Sequence and Domain Family The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7.
Swiss-Prot Key P15313_HUMAN
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