Anti-VCAM1 Antibody

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Product name Anti-VCAM1 Antibody
Short Description Rabbit monoclonal to VCAM1
Description This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
Applications IF, IHC, IP, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:20 - 1:50
Protein Name Vascular cell adhesion protein 1
V-CAM 1
VCAM-1
INCAM-100
CD antigen CD106
Immunogen Recombinant protein of human VCAM1
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF IP
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 7412
Gene Symbol VCAM1
Molecular Weight 81.276 kDa
Database Links HGNC:12663
OMIM:192225
Reactome:R-HSA-198933
Alternative Names Vascular cell adhesion protein 1
V-CAM 1
VCAM-1
INCAM-100
CD antigen CD106
Function Important in cell-cell recognition, Appears to function in leukocyte-endothelial cell adhesion, Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction, The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation
Post-translational Modifications Sialoglycoprotein
Cellular Localization Membrane
Tissue Specificity Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue
Swiss-Prot Key P19320
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