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Anti-VGF antibody

[STJ96661] Download PDF Print Data Sheet
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Product name Anti-VGF antibody
Short Description Rabbit polyclonal to VGF.
Description VGF is a protein encoded by the VGF gene which is approximately 67,2 kDa. VGF is secreted and is involved in growth factor activity and neuropeptide hormone activity. VGF is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. It may be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. VGF is expressed in the central and peripheral nervous systems, it is synthesized exclusively in neuronal and neuroendocrine cells. Mutations in the VGF gene may result in pulmonary large cell Neuroendocrine Carcinoma and Pheochromocytoma. STJ96661 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of VGF protein.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
Specificity VGF Polyclonal Antibody detects endogenous levels of VGF protein.
Protein Name Neurosecretory protein VGF
Neuroendocrine regulatory peptide-1
NERP-1
Neuroendocrine regulatory peptide-2
NERP-2
Antimicrobial peptide VGF
554-577
Immunogen Synthesized peptide derived from human VGF.
Immunogen Region 441-490 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7425
Gene Symbol VGF
Molecular Weight 67 kDa
Database Links HGNC:12684
OMIM:602186
Alternative Names Neurosecretory protein VGF antibody
Neuroendocrine regulatory peptide-1 antibody
NERP-1 antibody
Neuroendocrine regulatory peptide-2 antibody
NERP-2 antibody
Antimicrobial peptide VGF antibody
554-577 antibody
Function May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release. Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.
Post-translational Modifications Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
Cellular Localization Secreted Cytoplasmic vesicle, secretory vesicle. Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
Tissue Specificity Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
Swiss-Prot Key O15240_HUMAN
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