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Anti-WAVE2 antibody

[STJ96263] Download PDF Print Data Sheet

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Product name Anti-WAVE2 antibody
Short Description Rabbit polyclonal to WAVE2.
Description WAVE2 is a protein encoded by the WASF2 gene which is approximately 54,2 kDa. WAVE2 is localised to the cytoplasm and is involved in regulation of actin dynamics for phagocytic cup formation, innate immune system, signalling by Rho GTPases and RET signalling. It is a downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton and is expressed in all tissues. Mutations in the WASF2 gene may result in Wiskott-Aldrich syndrome and depression. STJ96263 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of WAVE2 protein.
Applications ELISA, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Specificity WAVE2 Polyclonal Antibody detects endogenous levels of WAVE2 protein.
Protein Name Wiskott-Aldrich syndrome protein family member 2
WASP family protein member 2
Protein WAVE-2
Verprolin homology domain-containing protein 2
Immunogen Synthesized peptide derived from human WAVE2
Immunogen Region 110-190 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 10163
Gene Symbol WASF2
Molecular Weight 55 kDa
Database Links HGNC:12733
OMIM:605875
Alternative Names WAVE2
Wiskott-Aldrich syndrome protein family member 2 antibody
WASP family protein member 2 antibody
Protein WAVE-2 antibody
Verprolin homology domain-containing protein 2 antibody
WAVE2 antibody
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Cellular Localization Cytoplasm, cytoskeleton Cell projection, lamellipodium. At the interface between the lamellipodial actin meshwork and the membrane.
Tissue Specificity Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.
Sequence and Domain Family Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.
Swiss-Prot Key Q9Y6W5_HUMAN
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